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Review Articles
Biomarkers of renal recovery after acute kidney injury
Rev Bras Ter Intensiva. 2017;29(3):373-381
Abstract
Review ArticlesBiomarkers of renal recovery after acute kidney injury
Rev Bras Ter Intensiva. 2017;29(3):373-381
DOI 10.5935/0103-507X.20170051
Views0ABSTRACT
Novel biomarkers can be suitable for early acute kidney injury diagnosis and the prediction of the need for dialysis. It remains unclear whether such biomarkers may also play a role in the prediction of recovery after established acute kidney injury or in aiding the decision of when to stop renal support therapy. PubMed, Web of Science and Google Scholar were searched for studies that reported on the epidemiology of renal recovery after acute kidney injury, the risk factors of recovery versus non-recovery after acute kidney injury, and potential biomarkers of acute kidney injury recovery. The reference lists of these articles and relevant review articles were also reviewed. Final references were selected for inclusion in the review based on their relevance. New biomarkers exhibited a potential role in the early diagnosis of acute kidney injury recovery. Urine HGF, IGFBP-7, TIMP-2 and NGAL may improve our ability to predict the odds and timing of recovery and eventually renal support withdrawal. Acute kidney injury recovery requires more study, and its definition needs to be standardized to allow for better and more powerful research on biomarkers because some of them show potential for the prediction of acute kidney injury recovery.
Keywords:Acute kidney injuryBiomarkersCritical careIntensive careRenal insufficiencyRenal replacement therapySee more -
Original Articles
Prognostics factors for mortality and renal recovery in critically ill patients with acute kidney injury and renal replacement therapy
Rev Bras Ter Intensiva. 2016;28(1):70-77
Abstract
Original ArticlesPrognostics factors for mortality and renal recovery in critically ill patients with acute kidney injury and renal replacement therapy
Rev Bras Ter Intensiva. 2016;28(1):70-77
DOI 10.5935/0103-507X.20160015
Views0ABSTRACT
Objective:
Identify prognostic factors related to mortality and non-recovery of renal function.
Methods:
A prospective single-center study was conducted at the intensive care medicine department of a university hospital between 2012 and 2015. Patients with acute kidney injury receiving continuous renal replacement therapy were included in the study. Clinical and analytical parameters were collected, and the reasons for initiation and discontinuation of renal replacement therapy were examined.
Results:
A total of 41 patients were included in the study, of whom 43.9% had sepsis. The median Simplified Acute Physiology Score II (SAPSII) was 56 and the mortality was 53.7%, with a predicted mortality of 59.8%. The etiology of acute kidney injury was often multifactorial (56.1%). Survivors had lower cumulative fluid balance (median = 3,600mL, interquartile range [IQR] = 1,175 – 8,025) than non-survivors (median = 12,000mL, IQR = 6,625 – 17,875; p = 0.004). Patients who recovered renal function (median = 51.0, IQR = 45.8 – 56.2) had lower SAPS II than those who do not recover renal function (median = 73, IQR = 54 – 85; p = 0.005) as well as lower fluid balance (median = 3,850, IQR = 1,425 – 8,025 versus median = 11,500, IQR = 6,625 – 16,275; p = 0.004).
Conclusions:
SAPS II at admission and cumulative fluid balance during renal support therapy were risk factors for mortality and non-recovery of renal function among critically ill patients with acute kidney injury needing renal replacement therapy.
Keywords:Acute kidney injuryInsufficiency renal, chronicIntensive careRenal insufficiencyRenal replacement therapySee more
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Case reports Child Coronavirus infections COVID-19 Critical care Critical illness Extracorporeal membrane oxygenation Infant, newborn Intensive care Intensive care units Intensive care units, pediatric mechanical ventilation Mortality Physical therapy modalities Prognosis Respiration, artificial Respiratory insufficiency risk factors SARS-CoV-2 Sepsis