You searched for:"Mirian Watanabe"
We found (3) results for your search.-
Original Articles
Urinary NGAL in patients with and without acute kidney injury in a cardiology intensive care unit
Rev Bras Ter Intensiva. 2014;26(4):347-354
Abstract
Original ArticlesUrinary NGAL in patients with and without acute kidney injury in a cardiology intensive care unit
Rev Bras Ter Intensiva. 2014;26(4):347-354
DOI 10.5935/0103-507X.20140053
Views0See moreObjective:
To assess the diagnostic and prognostic efficacy of urine neutrophil gelatinase-associated lipocalin in patients admitted to an intensive care unit.
Methods:
Longitudinal, prospective cohort study conducted in a cardiology intensive care unit. The participants were divided into groups with and without acute kidney injury and were followed from admission to the intensive care unit until hospital discharge or death. Serum creatinine, urine output and urine neutrophil gelatinase-associated lipocalin were measured 24 and 48 hours after admission.
Results:
A total of 83 patients admitted to the intensive care unit for clinical reasons were assessed, most being male (57.8%). The participants were divided into groups without acute kidney injury (N=18), with acute kidney injury (N=28) and with severe acute kidney injury (N=37). Chronic diseases, mechanical ventilation and renal replacement therapy were more common in the groups with acute kidney injury and severe acute kidney injury, and those groups exhibited longer intensive care unit stay and hospital stay and higher mortality. Serum creatinine did not change significantly in the group with acute kidney injury within the first 24 hours of admission to the intensive care unit, although, urine neutrophil gelatinase-associated lipocalin was high in the groups with acute kidney injury and severe acute kidney injury (p<0.001). Increased urine neutrophil gelatinase-associated lipocalin was associated with death.
Conclusion:
An increase in urine neutrophil gelatinase-associated lipocalin precedes variations in serum creatinine in patients with acute kidney injury and may be associated with death.
Views0
Abstract
Original ArticlesUrinary NGAL in patients with and without acute kidney injury in a cardiology intensive care unit
Rev Bras Ter Intensiva. 2014;26(4):347-354
DOI 10.5935/0103-507X.20140053
Views0See moreObjective:
To assess the diagnostic and prognostic efficacy of urine neutrophil gelatinase-associated lipocalin in patients admitted to an intensive care unit.
Methods:
Longitudinal, prospective cohort study conducted in a cardiology intensive care unit. The participants were divided into groups with and without acute kidney injury and were followed from admission to the intensive care unit until hospital discharge or death. Serum creatinine, urine output and urine neutrophil gelatinase-associated lipocalin were measured 24 and 48 hours after admission.
Results:
A total of 83 patients admitted to the intensive care unit for clinical reasons were assessed, most being male (57.8%). The participants were divided into groups without acute kidney injury (N=18), with acute kidney injury (N=28) and with severe acute kidney injury (N=37). Chronic diseases, mechanical ventilation and renal replacement therapy were more common in the groups with acute kidney injury and severe acute kidney injury, and those groups exhibited longer intensive care unit stay and hospital stay and higher mortality. Serum creatinine did not change significantly in the group with acute kidney injury within the first 24 hours of admission to the intensive care unit, although, urine neutrophil gelatinase-associated lipocalin was high in the groups with acute kidney injury and severe acute kidney injury (p<0.001). Increased urine neutrophil gelatinase-associated lipocalin was associated with death.
Conclusion:
An increase in urine neutrophil gelatinase-associated lipocalin precedes variations in serum creatinine in patients with acute kidney injury and may be associated with death.
-
Original Articles
Renoprotective effect of statin: a ischemia-reperfusion animal model
Rev Bras Ter Intensiva. 2010;22(3):245-249
Abstract
Original ArticlesRenoprotective effect of statin: a ischemia-reperfusion animal model
Rev Bras Ter Intensiva. 2010;22(3):245-249
DOI 10.1590/S0103-507X2010000300005
Views0OBJECTIVE: Ischemic acute kidney injury (iLRA), with multifatorial cause, presents alarming morbidity and mortality. Statin, HMG-CoA inhibition reductase has shown a renoprotective effect, with antioxidant, antiinflamatory and vascular actions. The heme oxygenase-1 (HO-1) can be involved in these pleitropic effects of statin on the renal function. This study was performed in order to evaluate if the renoprotective effect of the statin is a heme mechanism of protection in rats. METHODS: The ischemic model was reproduced by through clamping the bilateral renal pedicles for 30 minutes followed by reperfusion. Adult Wistar rats, weighting from 250-300g, were divided into the following groups: SHAM (control); Ischemia (30 minutes renal ischemia); Ischemia+Statin (sinvastatin 0.5mg/kg,orally (v.o.) for 3 days); Ischemia+Hemin (Hemin, 1.0mg/100g, intraperitoneal (i.p.), 24 hours before surgery); Ischemia+SnPP (SnPP 2μmol/kg, i.p., 24 hours before surgery ); Ischemia+Statin+Hemin; Ischemia+Statin+SnPP. RF (clearance of creatinine, Jaffé method), urinary peroxides (UP), urinary osmolality (UO) and immunohistochemical for ED-1 were evaluated. RESULTS: Results showed that sinvastatin ameliorated RF, urinary osmolality, reduced the UP excrection and the macrophage infiltration in rats submitted to renal ischemia. The inducer of HO-1 and its association with sinvastatin induced a similar pattern of improvement of renal function. CONCLUSION: the study confirmed the renoprotective effect of the statins on renal function, with antioxidant and antiinflamatory actions, and it suggests that this effect can have an interface with the heme system of renal protection.
Keywords:Heme oxygenase-1Hydroxymethylglutaryl-CoA reductase inhibitorsKidneyRats, WistarSimvastatinSee moreViews0Abstract
Original ArticlesRenoprotective effect of statin: a ischemia-reperfusion animal model
Rev Bras Ter Intensiva. 2010;22(3):245-249
DOI 10.1590/S0103-507X2010000300005
Views0OBJECTIVE: Ischemic acute kidney injury (iLRA), with multifatorial cause, presents alarming morbidity and mortality. Statin, HMG-CoA inhibition reductase has shown a renoprotective effect, with antioxidant, antiinflamatory and vascular actions. The heme oxygenase-1 (HO-1) can be involved in these pleitropic effects of statin on the renal function. This study was performed in order to evaluate if the renoprotective effect of the statin is a heme mechanism of protection in rats. METHODS: The ischemic model was reproduced by through clamping the bilateral renal pedicles for 30 minutes followed by reperfusion. Adult Wistar rats, weighting from 250-300g, were divided into the following groups: SHAM (control); Ischemia (30 minutes renal ischemia); Ischemia+Statin (sinvastatin 0.5mg/kg,orally (v.o.) for 3 days); Ischemia+Hemin (Hemin, 1.0mg/100g, intraperitoneal (i.p.), 24 hours before surgery); Ischemia+SnPP (SnPP 2μmol/kg, i.p., 24 hours before surgery ); Ischemia+Statin+Hemin; Ischemia+Statin+SnPP. RF (clearance of creatinine, Jaffé method), urinary peroxides (UP), urinary osmolality (UO) and immunohistochemical for ED-1 were evaluated. RESULTS: Results showed that sinvastatin ameliorated RF, urinary osmolality, reduced the UP excrection and the macrophage infiltration in rats submitted to renal ischemia. The inducer of HO-1 and its association with sinvastatin induced a similar pattern of improvement of renal function. CONCLUSION: the study confirmed the renoprotective effect of the statins on renal function, with antioxidant and antiinflamatory actions, and it suggests that this effect can have an interface with the heme system of renal protection.
Keywords:Heme oxygenase-1Hydroxymethylglutaryl-CoA reductase inhibitorsKidneyRats, WistarSimvastatinSee more -
Acute kidney injury by glycerol: antioxidant effect of Vitis vinifera L
Rev Bras Ter Intensiva. 2007;19(3):292-296
Abstract
Acute kidney injury by glycerol: antioxidant effect of Vitis vinifera L
Rev Bras Ter Intensiva. 2007;19(3):292-296
DOI 10.1590/S0103-507X2007000300004
Views0See moreBACKGROUND AND OBJECTIVES: The Acute Kidney Injury (AKI) is the most serious complication of rhabdomyolysis. In this syndrome, the delivery of heme pigment induces an injury that distinguishes itself by glomerular vasoconstriction and direct cellular toxicity with oxidative component. The renoprotection with antioxidants has demonstrated satisfactory effect. The proanthocyanidins are natural antioxidants found in the grape seed extract. The aim of this study was to evaluate the antioxidant effect of Vitis vinifera (grape seed extract) on the renal function of rats submitted to the injury by rhabdomyolysis. METHODS: Wistar rats, male, adults, weight ranging from 250-300g were used. The AKI was induced by intramuscular administration of glycerol 50%. The animals were distributed in 4 groups: Saline group (6 mL/kg of NaCl 0.9% intraperitoneal once a day), Glycerol group (6 mL/kg) of intramuscular glycerol each femoral region received 3 mL/kg of glycerol, once a day), Vitis vinifera group (3 mg/kg/day v.o by 5 days) and Glycerol + Vitis vinifera by 5 days before glycerol). RESULTS: Renal function (RF-creatinine clearance) and oxidative profile (urinary peroxides-FOX-2 and MDA-TBARS) were evaluted. The Glycerol group treated with Vitis vinifera has shown improvements in RF and reduction levels of lipid peroxidation. CONCLUSION: The results of this study have confirmed the antioxidant protection of Vitis vinifera in AKI induced by glycerol.
Views0Abstract
Acute kidney injury by glycerol: antioxidant effect of Vitis vinifera L
Rev Bras Ter Intensiva. 2007;19(3):292-296
DOI 10.1590/S0103-507X2007000300004
Views0See moreBACKGROUND AND OBJECTIVES: The Acute Kidney Injury (AKI) is the most serious complication of rhabdomyolysis. In this syndrome, the delivery of heme pigment induces an injury that distinguishes itself by glomerular vasoconstriction and direct cellular toxicity with oxidative component. The renoprotection with antioxidants has demonstrated satisfactory effect. The proanthocyanidins are natural antioxidants found in the grape seed extract. The aim of this study was to evaluate the antioxidant effect of Vitis vinifera (grape seed extract) on the renal function of rats submitted to the injury by rhabdomyolysis. METHODS: Wistar rats, male, adults, weight ranging from 250-300g were used. The AKI was induced by intramuscular administration of glycerol 50%. The animals were distributed in 4 groups: Saline group (6 mL/kg of NaCl 0.9% intraperitoneal once a day), Glycerol group (6 mL/kg) of intramuscular glycerol each femoral region received 3 mL/kg of glycerol, once a day), Vitis vinifera group (3 mg/kg/day v.o by 5 days) and Glycerol + Vitis vinifera by 5 days before glycerol). RESULTS: Renal function (RF-creatinine clearance) and oxidative profile (urinary peroxides-FOX-2 and MDA-TBARS) were evaluted. The Glycerol group treated with Vitis vinifera has shown improvements in RF and reduction levels of lipid peroxidation. CONCLUSION: The results of this study have confirmed the antioxidant protection of Vitis vinifera in AKI induced by glycerol.
Search
Search in:
KEY WORDS
Case reports Child Coronavirus infections COVID-19 Critical care Critical illness Extracorporeal membrane oxygenation Infant, newborn Intensive care Intensive care units Intensive care units, pediatric mechanical ventilation Mortality Physical therapy modalities Prognosis Respiration, artificial Respiratory insufficiency risk factors SARS-CoV-2 Sepsis