Monitoring, intraoperative Archives - Critical Care Science (CCS)

  • Original Article

    Goal-directed therapy guided by the FloTrac sensor in major surgery: a systematic review and meta-analysis

    Crit Care Sci. 2024;36:e20240196en

    Abstract

    Original Article

    Goal-directed therapy guided by the FloTrac sensor in major surgery: a systematic review and meta-analysis

    Crit Care Sci. 2024;36:e20240196en

    DOI 10.62675/2965-2774.20240196-en

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    ABSTRACT

    Objective

    To provide insights into the potential benefits of goal-directed therapy guided by FloTrac in reducing postoperative complications and improving outcomes.

    Methods

    We performed a systematic review and meta-analysis of randomized controlled trials to evaluate goal-directed therapy guided by FloTrac in major surgery, comparing goal-directed therapy with usual care or invasive monitoring in cardiac and noncardiac surgery subgroups. The quality of the articles and evidence were evaluated with a risk of bias tool and GRADE.

    Results

    We included 29 randomized controlled trials with 3,468 patients. Goal-directed therapy significantly reduced the duration of hospital stay (mean difference -1.43 days; 95%CI 2.07 to -0.79; I2 81%), intensive care unit stay (mean difference -0.77 days; 95%CI -1.18 to -0.36; I2 93%), and mechanical ventilation (mean difference -2.48 hours, 95%CI -4.10 to -0.86, I2 63%). There was no statistically significant difference in mortality, myocardial infarction, acute kidney injury or hypotension, but goal-directed therapy significantly reduced the risk of heart failure or pulmonary edema (RR 0.46; 95%CI 0.23 - 0.92; I2 0%).

    Conclusion

    Goal-directed therapy guided by the FloTrac sensor improved clinical outcomes and shortened the length of stay in the hospital and intensive care unit in patients undergoing major surgery. Further research can validate these results using specific protocols and better understand the potential benefits of FloTrac beyond these outcomes.

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