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Original Article
Lack of change in the respiratory quotient during oxygen supply dependence in endotoxemic shock: a subanalysis of an experimental controlled study
- Arnaldo Dubin ,
- Juan Francisco Caminos Eguillor ,
- Gonzalo Ferrara ,
- María Guillermina Buscetti ,
- Héctor Saúl Canales , [ … ],
- Vanina Siham Kanoore Edul
Abstract
Original ArticleLack of change in the respiratory quotient during oxygen supply dependence in endotoxemic shock: a subanalysis of an experimental controlled study
Crit Care Sci. 2023;35(3):281-289
DOI 10.5935/2965-2774.20230041-pt
- Arnaldo Dubin ,
- Juan Francisco Caminos Eguillor ,
- Gonzalo Ferrara ,
- María Guillermina Buscetti ,
- Héctor Saúl Canales ,
- Bernardo Lattanzio ,
- Luis Gatti ,
- Facundo Javier Gutierrez ,
- Vanina Siham Kanoore Edul
Views6See moreABSTRACT
Objective:
To evaluate if the reductions in systemic and renal oxygen consumption are associated with the development of evidence of anaerobic metabolism.
Methods:
This is a subanalysis of a previously published study. In anesthetized and mechanically ventilated sheep, we measured the respiratory quotient by indirect calorimetry and its systemic, renal, and intestinal surrogates (the ratios of the venous-arterial carbon dioxide pressure and content difference to the arterial-venous oxygen content difference. The Endotoxemic Shock Group (n = 12) was measured at baseline, after 60 minutes of endotoxemic shock, and after 60 and 120 minutes of fluid and norepinephrine resuscitation, and the values were compared with those of a Control Group (n = 12) without interventions.
Results:
Endotoxemic shock decreased systemic and renal oxygen consumption (6.3 [5.6 – 6.6] versus 7.4 [6.3 – 8.5] mL/minute/kg and 3.7 [3.3 – 4.5] versus 5.4 [4.6 – 9.4] mL/minute/100g; p < 0.05 for both). After 120 minutes of resuscitation, systemic oxygen consumption was normalized, but renal oxygen consumption remained decreased (6.3 [5.9 - 8.2] versus 7.1 [6.1 – 8.6] mL/minute/100g; p = not significance and 3.8 [1.9 – 4.8] versus 5.7 [4.5 – 7.1]; p < 0.05). The respiratory quotient and the systemic, renal and intestinal ratios of the venous-arterial carbon dioxide pressure and content difference to the arterial-venous oxygen content difference did not change throughout the experiments.
Conclusion:
In this experimental model of septic shock, oxygen supply dependence was not associated with increases in the respiratory quotient or its surrogates. Putative explanations for these findings are the absence of anaerobic metabolism or the poor sensitivity of these variables in detecting this condition.
Views6Abstract
Original ArticleLack of change in the respiratory quotient during oxygen supply dependence in endotoxemic shock: a subanalysis of an experimental controlled study
Crit Care Sci. 2023;35(3):281-289
DOI 10.5935/2965-2774.20230041-pt
- Arnaldo Dubin ,
- Juan Francisco Caminos Eguillor ,
- Gonzalo Ferrara ,
- María Guillermina Buscetti ,
- Héctor Saúl Canales ,
- Bernardo Lattanzio ,
- Luis Gatti ,
- Facundo Javier Gutierrez ,
- Vanina Siham Kanoore Edul
Views6See moreABSTRACT
Objective:
To evaluate if the reductions in systemic and renal oxygen consumption are associated with the development of evidence of anaerobic metabolism.
Methods:
This is a subanalysis of a previously published study. In anesthetized and mechanically ventilated sheep, we measured the respiratory quotient by indirect calorimetry and its systemic, renal, and intestinal surrogates (the ratios of the venous-arterial carbon dioxide pressure and content difference to the arterial-venous oxygen content difference. The Endotoxemic Shock Group (n = 12) was measured at baseline, after 60 minutes of endotoxemic shock, and after 60 and 120 minutes of fluid and norepinephrine resuscitation, and the values were compared with those of a Control Group (n = 12) without interventions.
Results:
Endotoxemic shock decreased systemic and renal oxygen consumption (6.3 [5.6 – 6.6] versus 7.4 [6.3 – 8.5] mL/minute/kg and 3.7 [3.3 – 4.5] versus 5.4 [4.6 – 9.4] mL/minute/100g; p < 0.05 for both). After 120 minutes of resuscitation, systemic oxygen consumption was normalized, but renal oxygen consumption remained decreased (6.3 [5.9 - 8.2] versus 7.1 [6.1 – 8.6] mL/minute/100g; p = not significance and 3.8 [1.9 – 4.8] versus 5.7 [4.5 – 7.1]; p < 0.05). The respiratory quotient and the systemic, renal and intestinal ratios of the venous-arterial carbon dioxide pressure and content difference to the arterial-venous oxygen content difference did not change throughout the experiments.
Conclusion:
In this experimental model of septic shock, oxygen supply dependence was not associated with increases in the respiratory quotient or its surrogates. Putative explanations for these findings are the absence of anaerobic metabolism or the poor sensitivity of these variables in detecting this condition.
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Case reports Child Coronavirus infections COVID-19 Critical care Critical illness Extracorporeal membrane oxygenation Infant, newborn Intensive care Intensive care units Intensive care units, pediatric mechanical ventilation Mortality Physical therapy modalities Prognosis Respiration, artificial Respiratory insufficiency risk factors SARS-CoV-2 Sepsis