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You searched for:"João Batista Raposo Mazullo Filho"

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  • Original Articles – Basic Research

    The effects of mechanical ventilation on oxidative stress

    Rev Bras Ter Intensiva. 2012;24(1):23-29

    Abstract

    Original Articles – Basic Research

    The effects of mechanical ventilation on oxidative stress

    Rev Bras Ter Intensiva. 2012;24(1):23-29

    DOI 10.1590/S0103-507X2012000100004

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    OBJECTIVE: Mechanical ventilation is a mainstay of therapy in intensive care units; however, its deleterious effects need to be assessed. Therefore, we aimed to assess oxidative stress in patients admitted to an intensive care unit undergoing invasive mechanical ventilation. METHODS: This cross-sectional study included 12 invasive mechanical ventilation patients. Blood samples (3 mL) were collected on the first and last days on invasive mechanical ventilation. Thiobarbituric acid-reacting substances (TBARS) were assessed in plasma, and superoxide dismutase (SOD) and catalase (CAT) were assessed in erythrocytes. RESULTS: The mean age was 64.8 ± 17.6 years, the tidal volume (VT) 382 ± 44.5 mL, and the APACHE II score 15 ± 7. When initial and final TBARS were compared, a significant difference was identified (3.54 ± 0.74 vs. 4.96 ± 1.47, p = 0.04). Antioxidant enzymes showed no significant differences. Correlations between PaO2/FiO2 and TBARS (r = 0.4), SOD and PaO2/FiO2 (r = 0.51) and APACHE II and SOD (r = 0.56) were identified. Six patients died. CONCLUSION: Patients undergoing invasive mechanical ventilation can develop redox state changes, showing increased TBARS and reduced antioxidant enzymes.

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    The effects of mechanical ventilation on oxidative stress
  • Noninvasive mechanical ventilation in immediate postoperative cardiac surgery patients

    Rev Bras Ter Intensiva. 2010;22(4):363-368

    Abstract

    Noninvasive mechanical ventilation in immediate postoperative cardiac surgery patients

    Rev Bras Ter Intensiva. 2010;22(4):363-368

    DOI 10.1590/S0103-507X2010000400009

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    BACKGROUND: : Noninvasive ventilation is routine in acute respiratory failure patients; nevertheless, the literature is controversial for its use in cardiac surgery postoperative period. OBJECTIVE: To evaluate the effectiveness of preventive noninvasive ventilation in the immediate postoperative period of cardiac surgery, monitoring its impact until the sixth day of hospitalization. METHODS: This was a controlled study, where patients in immediate postoperative period of cardiac surgery were randomized into two groups: control (G1) and investigational (G2) which received noninvasive ventilation set on pressure support mode and positive end expiratory pressure, for 2 hours following extubation. Were evaluated ventilatory, hemodynamical and oxygenation variables both immediately after extubation and after noninvasive ventilation in G2. RESULTS: Thirty-two patients completed the study, 18 in G1 and 14 in G2. The mean age was 61±16.23 years for G1 and for G2 61.5 ± 9.4 years. Of the initial twenty-seven patients in G1, nine patients (33.3%) were excluded due to invasive ventilation requirements, and three patients (11.11%) had to go back to invasive mechanical ventilation. None of the 14 G2 patients was reintubated. Patients undergoing early ventilatory support showed better results in the assessments throughout the hospitalization time. CONCLUSION: Noninvasive post-cardiac surgery ventilation was proven effective, as demonstrated by increased vital capacity, decreased respiratory rate, prevention of post-extubation acute respiratory failure and reduced reintubation rates.

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    Noninvasive mechanical ventilation in immediate postoperative cardiac surgery patients

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