You searched for:"Eurípedes Badaró"
We found (1) results for your search.-
Original Article
Role of interleukin-3 as a prognostic marker in septic patients
Rev Bras Ter Intensiva. 2018;30(4):443-452
Abstract
Original ArticleRole of interleukin-3 as a prognostic marker in septic patients
Rev Bras Ter Intensiva. 2018;30(4):443-452
DOI 10.5935/0103-507X.20180064
Views0See moreABSTRACT
Objective:
To evaluate the accuracy of IL-3 to predict the outcome of septic patients.
Methods:
Prospective cohort study with adult patients in an intensive care unit with sepsis or septic shock diagnosed within the previous 48 hours. Circulating IL-3 levels were measured upon inclusion (day 1) and on days 3 and 7. The primary outcome was hospital mortality.
Results:
One hundred and twenty patients were included. Serum levels of IL-3 on day 1 were significantly higher among patients who died than among patients who survived the hospital stay (91.2pg/mL versus 36pg/mL, p = 0.024). In a Cox survival model considering the IL-3 levels at inclusion, age and sequential SOFA, IL-3 values remained independently associated with mortality (HR 1.032; 95%CI 1.010 – 1.055; p = 0.005). An receiver operating characteristic curve was built to further investigate the accuracy of IL-3, with an area under the curve of 0.62 (95%CI 0.51 – 0.73; p = 0.024) for hospital mortality. A cutoff initial IL-3 value above 127.5pg/mL was associated with hospital mortality (OR 2.97; 95%CI: 1.27 – 6.97; p = 0.0019) but with a low performance (82% for specificity, 39% for sensibility, 53% for the positive predictive value, 72% for the negative predictive value, 0.73 for the negative likelihood and 2.16 for the positive likelihood ratio).
Conclusion:
Higher levels of IL-3 are shown to be independently associated with hospital mortality in septic patients but with poor clinical performance.
Search
Search in:
KEY WORDS
Case reports Child Coronavirus infections COVID-19 Critical care Critical illness Extracorporeal membrane oxygenation Infant, newborn Intensive care Intensive care units Intensive care units, pediatric mechanical ventilation Mortality Physical therapy modalities Prognosis Respiration, artificial Respiratory insufficiency risk factors SARS-CoV-2 Sepsis