Outcomes of critically ill pregnant COVID-19 patients: a cohort study - Critical Care Science (CCS)
Crit Care Sci. 2023;35(4):411-412
Information related to coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), in pregnant women is scarce and limited. Increased oxygen consumption, a reduction in chest wall compliance, and decreased functional residual capacity can exacerbate respiratory distress and may lead to the development of acute respiratory distress syndrome (ARDS).() Despite the magnitude of this research question, few studies have reported outcomes in this population.(-)
This retrospective cohort study included patients admitted to a tertiary intensive care unit (ICU) between June 2020 and May 2021. This study was approved according to national guidelines (Plataforma Brasil 66240017.0.0000.5530). We included patients admitted to the ICU with confirmed SARS-CoV-2 pneumonia. We separately analyzed pregnant patients at any gestational week and the rest of the population of patients admitted to the unit during the same period. Data on the following clinical characteristics were collected: age, sex, comorbidities, Simplified Acute Physiology Score (SAPS 3), and Sequential Organ Failure Assessment (SOFA) score at ICU admission. The primary outcome was the in-hospital mortality rate. The secondary outcome was the number of ventilation-free days (VFDs). The VFDs were defined as the number of days that patients were both alive and free of invasive mechanical ventilation (MV) at 28 and 60 days.
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Information related to coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), in pregnant women is scarce and limited. Increased oxygen consumption, a reduction in chest wall compliance, and decreased functional residual capacity can exacerbate respiratory distress and may lead to the development of acute respiratory distress syndrome (ARDS).() Despite the magnitude of this research question, few studies have reported outcomes in this population.(-)
This retrospective cohort study included patients admitted to a tertiary intensive care unit (ICU) between June 2020 and May 2021. This study was approved according to national guidelines (Plataforma Brasil 66240017.0.0000.5530). We included patients admitted to the ICU with confirmed SARS-CoV-2 pneumonia. We separately analyzed pregnant patients at any gestational week and the rest of the population of patients admitted to the unit during the same period. Data on the following clinical characteristics were collected: age, sex, comorbidities, Simplified Acute Physiology Score (SAPS 3), and Sequential Organ Failure Assessment (SOFA) score at ICU admission. The primary outcome was the in-hospital mortality rate. The secondary outcome was the number of ventilation-free days (VFDs). The VFDs were defined as the number of days that patients were both alive and free of invasive mechanical ventilation (MV) at 28 and 60 days.
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