Capillary leak syndrome during continuous renal replacement therapy after renal hilum ligation in a hypercapnic landrace pig - Critical Care Science (CCS)

Literature on dialysis in pigs is scarce, and there is no description of capillary leak syndrome during dialysis in pigs. Our aim in this paper is to bring attention to the possible occurrence of this syndrome, at least in the described specific condition.

In an ongoing experimental line of research, we are investigating the impact of high bicarbonate concentrations on blood pH during continuous venous-venous hemodialysis (CVVHD) in hypercapnic pigs with severe renal failure induced by hilum ligation.⁽⁾ In this described experiment, a female 31kg Landrace pig was used as the research subject. After anesthesia, a central venous line, venous dialysis catheter (12-French, 16cm, Arrow^TM, PA, USA), Swan-Ganz catheter (Edwards Lifesciences^TM, Irvine, USA), and an arterial line were inserted. After a median laparotomy, a cystostomy was performed (to ascertain anuria), and the renal hilum was ligated en bloc. The pig was stabilized for one hour after the end of the surgery. Then, the tidal volume was reduced to 2/3 (), and after one hour of tidal volume reduction, CVVHD was started.

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