coagulation profile in severe COVID-19 patients: what do we know so far? - Critical Care Science (CCS)

coagulation profile in severe COVID-19 patients: what do we know so far? |

Severe coronavirus disease 2019 (COVID-19) patients may present with single organ failure, but some of them progress to more systemic and multiple organ dysfunctions. One of the most significant markers of poor prognosis in those patients is the development of coagulopathy. These critically ill patients may have abnormal coagulation parameters, which may lead to hypercoagulability and increase the risk of thromboembolic events. Also, severe COVID-19 patients have been associated with disseminated intravascular coagulation (DIC) and increased risk of death.⁽⁾

In a recent publication, Tang et al.⁽⁾ retrospectively assessed the coagulation profile of 183 new coronavirus pneumonia patients (both survivors and non-survivors). Non-survivors had higher levels of D-dimer, fibrin degradation products, and longer prothrombin time on admission as compared to survivors. Moreover, the authors found that 71.4% of non-survivors had criteria for DIC. Also, non-survivors had lower levels of fibrinogen and antithrombin (AT) late during the hospitalization.

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