The use of hypothermia and outcome post cardiopulmonary resuscitation in 2014 - Critical Care Science (CCS)
In animal trials clinical outcome and histopathological damage of the brain tissue due to hypoxia after cardiac arrest was found to be reduced by mild therapeutic hypothermia.(,)
The clinical milestone trials in 2002 also have found mild therapeutic hypothermia at 32°-34 °C for 12-24 hours to be neuroprotective in treatment of the post-cardiac arrest syndrome.(–) The last update of the international guidelines for resuscitation in 2010 stressed the benefit of hypothermia to almost all patients after cardiac arrest that remain comatose after return of spontaneous circulation (ROSC).() Over the past much data have been published showing a significant benefit for neurological outcome in clinical practice besides large trials.
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In animal trials clinical outcome and histopathological damage of the brain tissue due to hypoxia after cardiac arrest was found to be reduced by mild therapeutic hypothermia.(,)
The clinical milestone trials in 2002 also have found mild therapeutic hypothermia at 32°-34 °C for 12-24 hours to be neuroprotective in treatment of the post-cardiac arrest syndrome.(-) The last update of the international guidelines for resuscitation in 2010 stressed the benefit of hypothermia to almost all patients after cardiac arrest that remain comatose after return of spontaneous circulation (ROSC).() Over the past much data have been published showing a significant benefit for neurological outcome in clinical practice besides large trials.
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