Dear Editor,
Intensive care unit (ICU) survivors suffer significant morbidity,(,) and longer mechanical ventilation (MV)-dependency increases the probability that these subjects will suffer a “persistent inflammation-immunosuppression and catabolism syndrome”.(–) These patients have ongoing inflammation, manageable organ failure, ongoing protein catabolism, and poor nutrition, leading to cachexia; poor wound healing and immunosuppression with increased susceptibility to secondary infections; and poor long-term survival.(,) These patients are classified as chronic critical illness (CCI) and present a protracted and complex ICU course that lasts for more than 7 days, they suffer from recurrent infections, organ dysfunction, malnutrition, weakness, cognitive decline, and prolonged institutionalization, and many fail to ever achieve functional independence and have poor long-term survival outcomes.(–)
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Dear Editor,
Intensive care unit (ICU) survivors suffer significant morbidity,(,) and longer mechanical ventilation (MV)-dependency increases the probability that these subjects will suffer a "persistent inflammation-immunosuppression and catabolism syndrome".(-) These patients have ongoing inflammation, manageable organ failure, ongoing protein catabolism, and poor nutrition, leading to cachexia; poor wound healing and immunosuppression with increased susceptibility to secondary infections; and poor long-term survival.(,) These patients are classified as chronic critical illness (CCI) and present a protracted and complex ICU course that lasts for more than 7 days, they suffer from recurrent infections, organ dysfunction, malnutrition, weakness, cognitive decline, and prolonged institutionalization, and many fail to ever achieve functional independence and have poor long-term survival outcomes.(-)
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