Improving the outcomes of sepsis in Brazil: strategies and initiatives - Critical Care Science (CCS)
Critical Care Science. 28/05/2025;37:e20250313
Sepsis represents a global health problem recognized by the World Health Organization (WHO) as a priority due to its high incidence, morbidity, mortality, and the substantial social and economic burden it imposes. The impact is especially severe in low- and middle-income countries (LMICs), which bear the brunt of the estimated 48 million sepsis cases and 11 million sepsis-related deaths annually.() Brazil exemplifies the challenges faced by LMIC, with considerable disparities in income, healthcare access, education, basic sanitation, and technology. Indicators such as low vaccination rates, high prevalence of preventable conditions, and an overburdened public health system highlight the country’s vulnerability to sepsis.
Septic patients may present at all levels of the healthcare system and must be recognized early and receive appropriate care wherever they are. Quality management of sepsis requires effective healthcare systems that can provide early recognition and detection of clinical deterioration, timely emergency care, targeted antimicrobial therapy, source control, intensive care management, prevention of complications, and adequate rehabilitation. Thus, an urgently needed global solution will require actions to reduce inequalities, from preventative measures to early recognition and fair treatment for all at-risk people.
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Sepsis represents a global health problem recognized by the World Health Organization (WHO) as a priority due to its high incidence, morbidity, mortality, and the substantial social and economic burden it imposes. The impact is especially severe in low- and middle-income countries (LMICs), which bear the brunt of the estimated 48 million sepsis cases and 11 million sepsis-related deaths annually.() Brazil exemplifies the challenges faced by LMIC, with considerable disparities in income, healthcare access, education, basic sanitation, and technology. Indicators such as low vaccination rates, high prevalence of preventable conditions, and an overburdened public health system highlight the country's vulnerability to sepsis.
Septic patients may present at all levels of the healthcare system and must be recognized early and receive appropriate care wherever they are. Quality management of sepsis requires effective healthcare systems that can provide early recognition and detection of clinical deterioration, timely emergency care, targeted antimicrobial therapy, source control, intensive care management, prevention of complications, and adequate rehabilitation. Thus, an urgently needed global solution will require actions to reduce inequalities, from preventative measures to early recognition and fair treatment for all at-risk people.
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