One-hour positive pressure ventilation after a successful spontaneous breathing trial: a multicenter feasibility randomized clinical trial - Critical Care Science (CCS)

INTRODUCTION

A small, randomized trial suggests that 1-hour positive pressure ventilation after a successful spontaneous breathing trial (SBT) on a T-piece may decrease extubation failure.⁽⁾ However, the effect on extubation failure was not statistically significant in another similar trial, despite a possible benefit for the subgroup of patients with more than 72 hours of mechanical ventilation (MV).⁽⁾ The primary objective of this study was to evaluate the feasibility of conducting large randomized controlled trials to determine whether, in patients with more than 72 hours of MV, 1-hour positive pressure ventilation following a successful SBT, either on T-piece or pressure support, reduces the risk of extubation failure within 7 days. Feasibility was defined as the capability to complete the study according to the planned schedule (enrolment within 6 months) and with adherence above 90% to the procedures in the experimental group (1-hour positive pressure ventilation [± 10 minutes] after an SBT followed by extubation) and control group (immediate extubation after an SBT).

Supplementary Material

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