Andexanet alfa for the management of severe bleeding: what should critical care physicians know about it? - Critical Care Science (CCS)

Oral anticoagulants are used for the prevention and treatment of arterial and venous thromboembolism. Over the past 20 years, there has been a shift from the use of vitamin K antagonists (VKAs) to the use of direct oral anticoagulants (DOACs).⁽⁾

Among DOACs, oral direct FXa inhibitors are increasingly being used for oral anticoagulation.⁽⁾ The in-hospital mortality rate is nearly 30% in patients with spontaneous intracranial hemorrhage (ICH) receiving FXa inhibitors, and the risk of mortality is higher in patients on FXa inhibitors than in those not on anticoagulants.⁽⁾

[…]